After securing a place in the Champions League round of 16, Inter Milan returned to the First Division on Saturday evening, as they seek to make up for what they lost by defeating struggling Sampdoria.
A true test of Leicester City's purple patch awaits them at King Power Stadium on Saturday lunchtime, as Premier League champions Manchester City pay a visit.
Manchester United will seek to claim at least the point they need to reach the Europa League knockout rounds when they face Sherif Tiraspol in Group E on Thursday night.
Barcelona will hope to still have a chance to reach the knockout stage of the Champions League when they welcome Bayern Munich at the Camp Nou on Wednesday night.
Real Madrid will bid to achieve four consecutive victories in the Spanish League and strengthen its grip on the first place in the table when it receives Sevilla at the Bernabeu on Saturday evening.
A fifth will attempt to overtake fourth in the exciting battle of Stamford Bridge on Saturday night, as Chelsea and Manchester United renew their feud in the Premier League.