Thursday's football match between Real Madrid and Cadiz will come to a close in the 14th round of the Spanish League season. Los Blancos is eager to defend their title.
Manchester United and Aston Villa are preparing for a second clash in a week, this time in the League Cup, a match that comes just four days after Villa's 3-1 victory over United in the Premier League.
Manchester United are seeking four consecutive wins in all competitions when they head to Villa Park in the Premier League on Sunday to face Aston Villa.
The north London derby brings together Chelsea and Arsenal at Stamford Bridge on Sunday lunchtime as Chelsea face Arsenal in the Premier League derby in London.
After losing the league last weekend with stunning success in Europe, Milan are back in action on Saturday, when they host struggling Spezia at the San Siro.
Bayern Munich can climb to the top of the Bundesliga table even if it's only for 24 hours - by achieving a positive away result against Hertha BSC on Saturday.
Having missed one chance to finish qualifying for the round of 16 of the Europa League, Arsenal will seek to take the lead in Group A when FC Zurich visits the Emirates Stadium on Thursday night.
The top spot in Group E in the European League is at stake at Anoeta Stadium on Thursday evening, as Real Sociedad and Manchester United meet to find out their fate by knockout.
Barcelona are looking to put their midweek Champions League disappointment behind them when they continue their La Liga campaign away to Valencia on Saturday night.
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