Olympique Marseille and Tottenham Hotspur will face off in the opening match of Group D in the Champions League on the back of strong starts to the season.
Arch rivals AC Milan and Inter Milan meet in the first derby della Madonnina of the season as the San Siro await a fiery showdown on Saturday afternoon.
Two struggling giants of the Premier League will face off at Stamford Bridge when Chelsea host West Ham United in the London derby in pursuit of the clash.
Hoffenheim have a chance of ending a four-game losing streak against Borussia Dortmund in the league match when they face them on Friday at Signal Iduna Park.