Arch rivals AC Milan and Inter Milan meet in the first derby della Madonnina of the season as the San Siro await a fiery showdown on Saturday afternoon.
Two struggling giants of the Premier League will face off at Stamford Bridge when Chelsea host West Ham United in the London derby in pursuit of the clash.
Hoffenheim have a chance of ending a four-game losing streak against Borussia Dortmund in the league match when they face them on Friday at Signal Iduna Park.
Liverpool will face a tough test against resilient Newcastle United as they try to build momentum after last weekend's record-breaking Premier League victory.