Liverpool will face a tough test against resilient Newcastle United as they try to build momentum after last weekend's record-breaking Premier League victory.
Unbeaten Juventus receive Spezia at Allianz Stadium in Serie A on Wednesday evening. Juventus' suffering continued as Massimiliano Allegri was injured by watching another midfielder limping against Roma last Saturday.
Arsenal receive Aston Villa at the Emirates Stadium in the fifth round match in the English Premier League. The home team returned from a 1-0 deficit to defeat Fulham 2-1 in its last match
Everton team is preparing to be a heavy guest against the Leeds United team led by its coach Jesse Marsh in the framework of the fifth week of the English Premier League
Milan is looking to extend its unbeaten run in 19 Serie A matches. Serie A returns to play midweek with the clubs involved in the first phase of the competition